Curcumin For Ostearthritis

Curcumin for Osteoarthritis

Image of Tumeric root and powder

Curcumin is a Ayurvedic herb that comes from the herb tumeric and has been used in India for centuries. A study published in the journal Alternative Medicine Review included 100 patients with osterarthritis.

The new study compared the effects of NSAIDs with NSAIDs plus the Meriva supplement – composed of 20 percent natural curcuminoid mixture, 40 percent phosphatidylcholine, and 40 percent microcrystalline cellulose. Subjects in the active group received a daily dose of 1,000 mg, which provided a daily curcumin dose of 200 mg. The control group received “best available treatment NSAID’s”.

Researchers followed the participants for eight months and found changes in the Western Ontario and McMaster Universities (WOMAC) score, used to measure the osteoarthritis variables, decreased from 80.6 to 33.2 in patients receiving NSAIDs plus the curcumin supplement. Researchers also reported that WOMAC scores for pain decreased by 9.3 points, while no change was observed in the control group. Stiffness decreased from 7.4 to 3.2, with no significant changes in the control group.

According to Indena, the combining the soy phosphatidylcholine with curcumin works to boost the bioavailability of the spice. Blending curcumin with soy phosphatidylcholine allows it to, “interact via hydrogen bondings and polar interactions with the complementary group, like the polar heads of phospholipids”, says Indena.

These findings suggest that curcumin may be a beneficial long-term therapy approach for people suffering with osteoarthritis.

 

Source: Alternative Medicine Review
Volume 15, Number 4, Pages 337-344
“Efficacy and Safety of Meriva, a Curcumin-phosphatidylcholine Complex, during Extended Administration in Osteoarthritis Patients”
Authors: G. Belcaro; M.R. Cesarone; M. Dugall; L. Pellegrini; A. Ledda; M.G. Grossi; S. Togni; G. Appendino

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Joint Savior is a comprehensive formula designed to help with joint mobility, inflammation, and pain. Joint Savior™ contains the popular Glucosamine, Chondroitin & MSM formula with 2 other effective ingredients CMO (Cetyl Myristoleate) and Hyaluronic Acid.

Glucosamine & Chondroitin

Glucosamin & Chondroitin have been a popular combination for joint support for the past 10 years. Glucosamine comes from the exoskeletons of crabs, shrimp & other shellfish. Glucosamine Sulfate has been used clinically in Europe since 1960’s and became popular in the US during the mid-1990’s after the release of the book “The Arthritis Cure” by Jason Theodosakis. Today Glucosamine is the most popular nutritional supplement with annual sales of more than $200 million a year.

The largest clinical trial on Glucosamine Sulfate & Chondroitin is being conducted by the National Institute of Health (NIH) with over 1,500 people involved. The studies found positive results with a 25% improvement as the placebo group. The positive results of the clinical trial not only showed a reduction in pain and swelling but also when combined with Chondroitin it slowed the progression of the disease and helped rebuild damaged cartilage.

Methyl-Sulfonyl-Methane (MSM)

MSM came from the research that was done on DMSO by Dr. Stanley W. Jacobs at the Oregon Health Science University. He learned that MSM was a stable metabolite of DMSO which was very stable and odorless.

A randomized, double-blind, placebo-controlled trial was conducted. Fifty men and women, 40-76 years of age with knee OA pain were enrolled in an outpatient medical center. MSM produced significant decreases in WOMAC (Western Ontario and McMaster University Osteoarthritis Index visual analogue scale) pain and physical function impairment (P<0.05).¹

Cetyl Myristoleate (CMO)

Harry Diehl, a research chemist at the NIH, discovered Cetyl Myristoleate after spending 2 years trying to isolate the substance that protected Swiss albino mice from getting arthritis. Harry Diehl proved that cetyl myristoleate circulates in the blood of mice that made them immune to arthritis. Harry Diehl was so ecstatic about his discovery he approached many large pharmaceutical companies to conduct human clinical trials on CMO. None of the companies were interested, however, because CMO was a natural substance and they would not be able to patent it.

Hyaluronic Acid

Hyaluronic acid (also called Hyaluronan) occurs in large amounts in many of the places that people with connective tissue disorders have problems such as the joints, the eyes, the skin, and heart valves. Hyaluronic acid is needed to cushion and lubricate joints, eyes, skin, and heart valves.

A study published in the February 2007 issue of food and Chemical Toxicology has confirmed the safety of oral hyaluronic acid. Hyaluronic acid is a dietary supplement that supports connect tissue health in joints and skin. The research was comprised of two oral toxicity studies involving acute and subchronic tests. Test subjects exhibited no toxicity, even at 33 times the recommended dose, as observed by a review of a variety of biomarkers and histopathological examinations.²

¹National Institutes of Health 2006 Mar, 14(3):286-94. Epub 2005 Nov 23

²Schauss, A.G., Merkel, D.J., Glaza, S.M., Sorenset, S.R. et al. (2007). Acute and subchronic oral toxicity studies in rats of a hyrolyzed chicken sternal cartilage preparation. Food and Chemical Toxicology, 45 (2), 315-321.

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

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Abnormal Levels of Hyaluronic Acid Linked to Connective Tissue Disorders

Hyaluronic acid (also called Hyaluronan) is a component of connective tissue whose function is to cushion and lubricate.  Hyaluronan occurs throughout the body in abundant amounts in many of the places people with hereditary connective tissue disorders have problems such as joints, heart valves and eyes.  Hyaluronic acid abnormalities are a common thread in connective tissue disorders.  Interestingly, they are also common biochemical anomalies in most of the individual features of connective tissue disorders such as mitral valve prolapse, TMJ, osteoarthritis, and keratoconus.

Hyaluronic acid has been nicknamed by the press as the “key to the fountain of youth” because it has been noted that at least some people who ingest a lot of it in their diets tend to live to ripe old ages. ABC News had a show on a village in Japan and hyaluronic acid entitled, “The Village of Long Life: Could Hyaluronic Acid Be an Anti-Aging Remedy?”. (It should be noted that the people in the ABC news show were thought to get high amounts of  Hyaluronic acid from starchy root vegetables their natural diets. They were not taking supplements.)

While a number of studies have linked abnormal levels of  Hyaluronic acid to either connective tissue disorders (CTDs) or conditions common in CTDs, such as premature aging, there are also a number of studies on Pubmed noting associations of high levels of  Hyaluronic acid to some forms of cancer. With Hyaluronic acid as with other substances in the human body, such as estrogen and cholesterol, there are most likely optimal levels, and disease often occurs when these levels become out of range in either direction. Low estrogen levels have been linked to bone loss, while high estrogen levels have been associated with breast cancer. High cholesterol levels have been linked to heart attacks and stroke, while low levels have been linked to bleeding problems and depression.  Hyaluronic acid has been studied less than either cholesterol or estrogen, but the prudent path would be to assume that the body has optimal levels of Hyaluronic acid, as it does for cholesterol, estrogen and many other substances.

As such, it is always prudent to consult your doctor before you decide to take Hyaluronic acid or any other type of supplement to make sure it is an appropriate treatment for your particular health condition.

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